Tricyclic compounds, a process for their preparation and pharmaceutical compositions containing them

A compound selected from those of formula (I):

• wherein
• A represents a 5, 6 or 7-membered aromatic or non-aromatic ring having 1 or 2 hetero atoms selected from oxygen, sulphur and nitrogen, wherein the nitrogen atom may optionally be substituted by a linear or branched (C1-C6)alkyl group, it being understood that ring A cannot contain 2 sulphur atoms or 2 oxygen atoms and that one of the ring members may be a C═O group,
• n and n′, which may be identical or different, represent 0, 1 or 2, where 0<n+n′<4,
• R3 represents an aryl or heteroaryl group,
• X represents a linear or branched alkylene chain having from 1 to 6 carbon atoms, wherein one or two of which carbon atoms may be replaced by an oxygen atom, a cycloalkylene group, an arylene group, a heteroarylene group or an SO2 group,
• one of R1 and R2 represents a hydrogen atom and the other represents a group of formula (II):
• wherein:
• Y represents a C═O or CH2 group,
• R5 represents a hydrogen atom and R6 represents a hydrogen atom or an —NR7R′7 or —CH2—NR7R′7 group wherein each of R7 and R′7, which may be identical or different, independently represents a hydrogen atom or a linear or branched (C1-C6)alkyl group substituted by one or more aryl, heteroaryl, aryloxy, heteroaryloxy, arylthio, heteroarylthio, heterocycloalkyl or —NR10R′10 groups wherein:
• R10 and R′10, which may be identical or different, are selected from hydrogen, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)alkoxy, aryl and heteroaryl, or
• R10 and R′10 form a saturated or unsaturated cyclic or bicyclic group which may contain a hetero atom selected from oxygen, nitrogen and sulphur, it being understood that one or more of the ring members may represent a C═O group, and wherein the cyclic or bicyclic group may be optionally substituted by from 1 to 3 groups selected from linear or branched (C1-C6)alkyl optionally substituted by a hydroxy or amino group, linear or branched (C1-C6)alkoxy, hydroxy, carboxy, formyl, nitro, cyano, amino, linear or branched polyhalo-(C1-C6)alkyl, alkoxycarbonyl and halogen atoms,
• or R5 and R6, together with the two carbon atoms carrying them, form an aromatic or non-aromatic ring having 5 or 6 ring members, one nitrogen atom of which being in the position para to the SO2 group, and which may contain in addition to the nitrogen atom a further nitrogen atom and/or an SO2 group, wherein the ring may be substituted by an R7 group as defined above,
• R4 represents a halogen atom or an NO2, R8, SO2—R9, linear or branched (C1-C6)-alkyl or linear or branched (C1-C6)alkoxy group, wherein R8 a hydrogen atom or a linear or branched (C1-C6)alkyl group substituted by one or more aryl, heteroaryl, aryloxy, heteroaryloxy, arylthio, heteroarylthio, heterocycloalkyl or —NR10R′10,
• R9 represents an amino group or a linear or branched (C1-C6)alkyl group optionally substituted by one or more halogen atoms,
• it being understood that:
• “aryl” means a phenyl, naphthyl or biphenyl group,
• “heteroaryl” means a mono- or bi-cyclic group having at least one aromatic moiety and having from 5 to 10 ring members which may contain from 1 to 3 hetero atoms selected from oxygen, sulphur and nitrogen,
• “heterocycloalkyl” means a mono- or bi-cyclic non-aromatic group having from 4 to 10 ring members which may contain from 1 to 3 hetero atoms selected from oxygen, sulphur and nitrogen,
• “cycloalkyl” means a mono- or bi-cyclic non-aromatic group containing from 4 to 10 ring members,
• wherein the aryl, heteroaryl, heterocycloalkyl and cycloalkyl may be optionally substituted by from 1 to 3 groups selected from linear or branched (C1-C6)alkyl optionally substituted by a hydroxy or amino group, linear or branched (C1-C6)alkoxy, hydroxy, carboxy, formyl, nitro, cyano, amino, linear or branched polyhalo-(C1-C6)alkyl, alkoxycarbonyl and halogen atoms, and
• “arylene”, “heteroarylene” and “cycloalkylene” mean, respectively, a bivalent aryl, heteroaryl or cycloalkyl group as defined above,
• its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base.