Glucocorticoid-lowering composition
OwnerSvyatoslav Komarnytsky, Dmitry Govorko +2inventors
InventorsSvyatoslav Komarnytsky, Dmitry Govorko, Joseph M. O'Neal, Ilya Raskin
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Abstract
This disclosure relates to a composition comprising pregnane derivatives according to Formula (I), or a salt, solvate or hydrate thereof, and to a pharmaceutically acceptable carrier or excipient. The composition may be used to lower glucocorticoid level in a human or animal. It may also be used tor modulate activity of enzymes of glucocorticoid metabolism, to modulate RNA transcription and protein level of hypothalamic, hippocampal and pituitary peptides, or for treatment or prophylaxis of human or animal diseases.
Claims19
A therapeutic method comprising administering to a subject who has a higher than normal glucocorticoid level a composition comprising a pregnane derivative according to Formula (I) or a salt, solvate or hydrate thereof, wherein said composition lowers the circulating glucocorticoid level.
A method of prophylaxis for a defect in central energy regulation or expenditure comprising administering to a subject a composition comprising a pregnane derivative according to Formula (I) or a salt, solvate or hydrate thereof, wherein said composition modifies the metabolism to decrease energy expenditure.
A method for modulating the activity of a factor or enzyme of glucocorticoid metabolism comprising contacting the factor or enzyme with a pregnane derivative according to Formula (I) or a salt, solvate or hydrate thereof.
A method for modulating RNA transcription of a hypothalamic, hippocampal or pituitary peptide comprising contacting a hypothalamic, hippocampal or pituitary cell with a pregnane derivative according to Formula (I) or a salt, solvate or hydrate thereof.
A method for modulating the level of a hypothalamic, hippocampal or pituitary peptide comprising contacting a hypothalamic, hippocampal or pituitary cell with a pregnane derivative according to Formula (I) or a salt, solvate or hydrate thereof.
Dependencies are inferred from the claim text.