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US 2008/0188438 A1Published application
Fra-1 expression in brain cancer
AssigneeThe Penn State Research Foundation
InventorsWaldemar Debinski, Denise M. Gibo
Life of this patent
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Abstract
Fra-1 serves as a target for diagnosing and treating glioblastoma multiforme and related brain cancers. Cancer in a brain tissue sample is detected by analyzing expression of Fra-1 in the sample. Brain cancer is treated by modulating Fra-1 gene expression in cells of the cancer, and by inhibiting angiogenesis associated with the cancer by interfering with Fra-1 binding to a VEGF-D promoter.
Claims7
A composition for treating cancer comprising an oligonucleotide molecule as identified by SEQ ID No.:
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Dependencies are inferred from the claim text.