Ligands Having Metal Binding Ability and Targeting Properties

A ligand comprising at least two separate domains wherein:

• one of the domains comprises a metal binding domain and one of the domains comprises a targeting domain targeted to a polynucleotide target, peptide target, or protein target;
• the metal binding domain is linked either directly to the targeting domain or by at least one linker;
• the ligand selectively degrades, inactivates, or inhibits the target via metal mediation;
• and
• the metal binding domain is selected from at least one of a modified or unmodified ATCUN motif, the PHGGGWGQ motif, a peptide motif having histidine as the first residue and glycine as the third residue from the N-terminus of the peptide motif;
• a peptide motif having histidine as the third residue from the N-terminus of the peptide motif, a zinc finger peptide having two cysteine and two histidine residues, a peptide conjugate with a synthetic metal binding motif, a peptide mimic, a cyclam, GGH, KGHK, VIHN, or YIHPF,