Parenteral Combination Therapy For Infective Conditions With Drug Resistant Bacterium

A process for preparing a pharmaceutical composition suitable for parenteral combination therapy for non-ocular infective conditions with drug resistant bacterium, comprising the steps of:

• a. sterile filling/blending said first and said second antibacterial agents, wherein said first antibacterial agent, being a first antibacterial active ingredient, is vancomycin or a first pharmaceutically acceptable salt thereof, such as vancomycin hydrochloride;
• wherein said second antibacterial agent, being a second active ingredient, is ceftriaxone or a second pharmaceutically acceptable salt thereof, such as ceftriaxone sodium;
• b. adding a particulate formation/precipitation inhibitor present in the form of a chemical vector;
• c. continuing said sterile filling/blending operation for a period of about 1 hour to about 8 hours;
• d. proportioning the sterile fill/blend of step (a) to get desired pharmaceutically effective dose in weight ratio of said first antibacterial agent to said second antibacterial agent in the range from about 1:4 to about 4:1 respectively;
• preferably in the range from about 1:3 to about 3:1 respectively;
• and more preferably in the range from about 1:2 to about 2:1 respectively;
• the range of said chemical vector being in the range from about 10% to about 40% of the total weight of the blended/filled composition;
• and
• e. e. capping aseptically with pre/post inert gassing.