Methods For Treating Bleeding

A method for treatment of bleeding in a patient, wherein the bleeding is associated with trauma, intracerebral hemorrhage (ICH), traumatic brain injury (TBI), burns, variceal bleeds, gastrointestinal bleeding, surgical bleeds, transplantation, fibrinolytic treatment, anticoagulant treatment, postpartum hemorrhage, viral-induced hemorrhage, thrombocytopenia, or factor deficiency, comprising administering to said patient a variant of a human FVII or FVIIa polypeptide that differs from SEQ ID NO:1 in 1-15 amino acid residues and has an increased phospholipid membrane binding affinity and/or an increased tissue factor independent activity relative to hFVIIa.