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US 2008/0187992 A1Published application
Methods for inhibiting tumor cell proliferation
AssigneeUniversity of South Florida
InventorsJames Turkson, Richard Jove, Jay W. Palmer, Heidi Kay, Hua Yu
Life of this patent
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Abstract
The subject invention concerns methods for inhibition of STAT biological functions using platinum complexes.
Claims12
A method for inhibiting a Stat3 transcription factor comprising contacting a cell expressing a Stat3 transcription factor with a platinum complex selected from the group consisting of
- or a pharmaceutically-acceptable salt thereof.
A method of inhibiting the function and/or growth and/or replication of a cell that is aberrrantly or constitutively expressing a STAT transcription factor, comprising contacting said cell with a platinum complex selected from the group consisting of:
- or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.