Biomarkers of Ionizing Radiation Response
AssigneeWisconsin Alumni Research Foundation
InventorsGabriela G. Cezar, Alan M. Smith
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Abstract
The invention provides methods for measuring cellular response to ionization radiation (IR). The invention also provides a plurality of diagnostic and prognostic cancer biomarkers for assessing cellular response to IR.
Claims39
A method for identifying a cellular metabolite or plurality of cellular metabolites differentially produced in cells exposed to ionizing radiation, the method comprising the steps of:
- a. assaying a biological sample for cellular metabolites prior to and after exposure to ionizing radiation, and
- b. identifying cellular metabolites having a molecular weight of from about 55 to about 3000 Daltons that are differentially produced in cells following ionizing radiation.
A method of monitoring cellular response to ionizing radiation, the method comprising the step of measuring phenylacetate or medium-chain acylcarnitines in a biological sample exposed to a therapeutic amount of ionizing radiation.
A method of monitoring glioma cell response to ionizing radiation, the method comprising the step of measuring phenylacetate in a biological sample exposed to a therapeutic amount of ionizing radiation.
A method for determining an individual's exposure to radiation, the method comprising measuring phenylacetate in a biological sample.
A method for identifying a cellular metabolite or a plurality of cellular metabolites differentially produced in cells exposed to ionizing radiation, the method comprising the steps of:
- a. assaying tumor cells for cellular metabolites prior to and after exposure to ionizing radiation, and
- b. identifying cellular metabolites having a molecular weight of from about 55 to about 3000 Daltons that are differentially produced in cells following ionizing radiation.
Dependencies are inferred from the claim text.