Single Nucleotide Polymorphisms in Protein-Tyrosine Phosphatase Receptor-Type Delta for the Diagnosis of Susceptibility to Infection and Asthma
AssigneeVita Genomics, Inc.
InventorsShih Hsin Wu, Ellson Ye-Shyon Chen
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Abstract
A gene related to a susceptibility of infection and asthma—the Protein-Tyrosine Phosphatase Receptor-type Delta (PTPRD) gene—a method of detecting the asthma-associated gene, a method of predicting the occurrence of asthma, a method of identifying asthma-associated alleles in PTPRD gene, a method of screening PTPRD for drugs useful in the treatment of asthma, and antibodies specific for PTPRD variants and their use in diagnostic assays.
Claims14
A method of determining susceptibility to asthma, said method comprising:
- a) obtaining a biological sample from a patient;
- b) detecting at least one allele within the Protein-Tyrosine Phosphatase Receptor-type Delta (PTPRD) gene;
- c) determining if said allele is associated with asthma, thereby indicating that the patient is susceptible to asthma.
A method of identifying alleles associated with susceptibility to asthma, said method comprising:
- a) obtaining biological samples from a population of patients having asthma and a population of patients not having asthma;
- b) identifying at least one allele in the PTPRD gene from each biological sample;
- and
- c) showing an association between said allele and said patients having asthma, but not with said patients not having asthma;
- and
- d) thereby identifying said allele as associated with susceptibility to asthma.
A method of determining susceptibility to asthma, comprising obtaining a biological sample from a patient and detecting at least one allele within the PTPRD gene, wherein said allele is a C at the rs2279776 loci or a G at the rs767674 loci, thereby indicating that the patient is susceptible to asthma.
14-16. (canceled)
Dependencies are inferred from the claim text.