Compositions and methods for repressing the Ink4a and Arf senescence pathways
AssigneeThe Regents of the University of Michigan
InventorsSean Morrison, Anna Molofsky, Ricardo Pardal
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Abstract
The present invention relates to methods and compositions for regulating cell growth and development. In particular, the present invention relates to methods and compositions for repressing Ink4a and Arf pathways.
Claims20
A method of promoting stem cell function comprising inhibiting the function of a gene selected from the group consisting of Arf and Ink4a in a stem cell.
A method of screening compounds, comprising contacting a neural stem cell that expresses a gene selected from the group consisting of Arf and Ink4a with a test compound;
- and comparing the level of proliferation in said neural stem cell in the presence of said test compound with said level in the absence of said test compound.
A method of screening compounds, comprising contacting a stem cell that expresses a gene selected from the group consisting of Arf and Ink4a with a test compound;
- and comparing the level of expression of said gene in the presence of said test compound with said level in the absence of said test compound.
Dependencies are inferred from the claim text.