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US 2008/0187908 A1Published application
Granulocyte Subtype-Selective Receptors And Ion Channels And Uses Thereof
OwnerChaker N. Adrainventor
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Abstract
The invention relates, in part, to granulocyte type selective markers that are preferentially expressed in granulocytes and their use in drug screening assays. Additionally, the granulocyte type selective markers are useful in the diagnosis and treatment of granulocyte disorders and in the assessment of the efficacy of therapies of granulocyte disorders.
Claims22
A method for diagnosing a granulocyte disorder comprising:
- detecting in a biological sample from a subject a level of expression of one or more granulocyte-selective markers,
- comparing the level of expression of each of the one or more granulocyte-selective markers with a reference level of expression, wherein a statistically significant difference between the level of expression of at least one granulocyte-selective marker and an expected level of expression for the at least one granulocyte-selective marker is indicative of a granulocyte disorder in the subject.
A method for diagnosing a non-neutrophil granulocyte disorder or mast cell disorder comprising:
- detecting in a biological sample from a subject a level of expression of one or more non-neutrophil granulocyte or mast cell selective markers,
- comparing the level of expression of each of the one or more non-neutrophil granulocyte or mast cell selective markers with a reference level of expression, wherein a statistically significant difference between the level of expression of at least one non-neutrophil granulocyte or mast cell selective marker and an expected level of expression for the at least one non-neutrophil granulocyte or mast cell selective marker is indicative of a non-neutrophil granulocyte disorder or mast cell disorder in the subject.
20-48. (canceled)
An assay for identifying a compound that alters at least one physiological property of a granulocyte comprising:
- contacting a granulocyte with a candidate compound that interacts with a granulocyte-selective marker,
- determining at least one physiological property of the granulocyte after contact with the candidate compound,
- comparing the at least one physiological property to one at least one reference property to determine whether the candidate compound alters at least one physiological property of the granulocyte.
50-71. (canceled)
Dependencies are inferred from the claim text.