Liquid chalcogenide compositions and methods of manufacturing and using the same
AssigneeIkaria, Inc.
InventorsKevin J. Tomaselli, Paul A. Hill, Thomas L. Deckwerth, Edward Wintner, Csaba Szabo
Life of this patent
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Abstract
The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.
Claims76
A composition comprising a stable liquid pharmaceutical chalcogenide or chalcogenide compound or salt or precursor thereof in a pharmaceutically acceptable carrier, wherein the concentration, pH and oxidation products of said chalcogenide or chalcogenide compound or salt remain within a range of acceptance criteria after storage of said liquid pharmaceutical composition.
A method of preparing a composition of a sulfide suitable for administration to an animal, comprising:
- a. dissolving one equivalent of hydrogen sulfide gas into one equivalent of liquid, thereby producing a composition of sulfide;
- and
- b. adjusting the pH of the composition resulting from step (a) to a pH in the range of 6.5 to 8.5, wherein said composition thereby producing a liquid composition of a sulfide suitable for administration to an animal.
A kit comprising one or more containers comprising a composition of a chalcogenide or chalcogenide salt, wherein said composition has a pH in the range of 6.5 to 8.5.
A method for treating human disease or injury of a biological material exposed to ischemic or hypoxic conditions comprising contacting the biological material with an effective amount of a composition of a chalcogenide or chalcogenide salt.
Dependencies are inferred from the claim text.