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US 2008/0187591 A1Published application
Rapidly acting dry sealant and methods for use and manufacture
AssigneesBaxter International Inc., Baxter Healthcare S.A.
InventorsWoonza M. Rhee, Cary J. Reich, A. Edward Osawa, Felix Vega
Life of this patent
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Abstract
Compositions, methods, and kits are provided for sealing applications. Compositions are prepared by combining a first cross-linkable component with a second cross-linkable component to form a porous matrix having interstices, and combining the porous matrix with a hydrogel-forming component to fill at least some of the interstices. The compositions exhibit minimal swelling properties.
Claims26
A composition comprising:
- a first cross-linkable component;
- a second cross-linkable component that cross-links with the first cross-linkable component under reaction enabling conditions;
- and
- a hydrogel-forming component;
- wherein the first and second cross-linkable component cross-link to form a porous matrix having interstices, and wherein the hydrogel-forming component is capable of being hydrated to form a hydrogel to fill at least some of the interstices.
2 more elements
A mixed powder composition comprising:
- a first cross-linkable component comprising multiple nucleophilic groups, the first cross-linkable component in powdered form;
- a second cross-linkable component comprising multiple electrophilic groups, the second cross-linkable component in powdered form;
- and
- a hydrogel-forming component in powdered form;
- wherein under reaction-enabling conditions the first and second cross-linkable components are capable of substantially immediate cross-linking.
2 more elements
A composition comprising:
- a collagen sponge comprising native collagen fibers;
- and
- a mixed powder composition fixed with a surface of the sponge, the mixed powder composition comprising:
- a first cross-linkable component comprising multiple nucleophilic groups, the first cross-linkable component in powdered form and comprising about 10% of the mixed powder;
- a second cross-linkable component comprising multiple electrophilic groups, the second cross-linkable component in powdered form and comprising about 10% of the mixed powder;
- and
- a hydrogel-forming component in powdered form, comprising about 80% of the mixed powder;
- wherein under reaction-enabling conditions the first and second cross-linkable components are capable of substantially immediate cross-linking to form a porous matrix having interstices, and the hydrogel-forming component is capable of being hydrated to form a hydrogel to fill at least some of the interstices.
5 more elements
Dependencies are inferred from the claim text.