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US 2008/0187590 A1Published application
Oral Dosage Form
OwnerKari Vahervuoinventor
Life of this patent
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Abstract
An oral dosage form of entacapone and methods for the preparation thereof are provided.
Claims42
An oral dosage form comprising a pharmacologically effective amount of entacapone as the sole drug substance, wherein the amount of entacapone in a portion of the oral dosage form is from 35% to 99% by weight of the portion.
A method for the preparation of a core tablet comprising
- (i) preparing a mixture of entacapone as the sole drug substance with at least one binder and optionally one or more other excipients, and granulating the mixture with a granulating liquids
- or granulating entacapone as the sole drug substance with at least one optional other excipient with a granulating liquid comprising at least one binder,
- or by melt granulation;
- (ii) drying or cooling, and optionally screening the granules of step (i), optionally bringing the granules into contact with at least one extragranular excipient;
- and
- (iii) compressing the granules and the at least one optional extragranular excipient into a core tablet.
3 more elements
A method for the preparation of granules of entacapone comprising
- (i) preparing a mixture of entacapone as the sole drug substance with a binder and optionally at least one other excipient, and granulating the mixture with a granulating liquid,
- or granulating entacapone as the sole drug substance with at least one optional other excipient with a granulating liquid comprising a binder, or by melt granulation;
- (ii) drying or cooling, and optionally screening the granules of step (i).
32-33. (canceled)
A method for the preparation of a capsule of entacapone comprising
- (i) preparing a mixture of entacapone as the sole drug substance with a binder and optionally at least one other excipient, and granulating the mixture with a granulating liquid,
- or granulating entacapone as the sole drug substance with at least one optional other excipient with a granulating liquid comprising a binder, or by melt granulation;
- (ii) drying or cooling, and optionally screening the granules of step (i), optionally bringing the granules into contact with at least one extragranular excipient;
- and
- (iii) filling the granules and at least one optional extragranular excipient into a suitable capsule.
2 more elements
Dependencies are inferred from the claim text.