Multi-modal delivery via transmucosal and gastro-intestinal absorption of antihistamines and symptom relief

A method of attaining relief from histamine effects and symptoms, comprising:

• orally administering a multi-modal absorption, medicine-delivery lozenge to an individual in need of relief of histamine effects and symptoms, the lozenge comprising a lozenge base for oral administration into the individual's mouth, a medicinal active ingredient comprising an antihistamine convertible between ionized and non-ionized forms, and a buffer;
• establishing a pH in the individual's mouth which is characterized by a simultaneous presence of a first pharmacologically effective dose of the non-ionized form of the medicinal active ingredient for transmucosal absorption, and a second pharmacologically effective dose of the ionized form of the medicinal active ingredient for gastrointestinal absorption;
• and
• permitting the medicinal active ingredient to cause relief from histamine effects and symptoms.