Pharmaceutical composition formulated for pre-gastric absorption of monoamine oxidase b inhibitor component
OwnerFrancesca Mary Brewer, Edward Stuart Johnson +1inventors
InventorsFrancesca Mary Brewer, Edward Stuart Johnson, Anthony Clarke
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Abstract
A fast dispersing solid pharmaceutical composition having a monoamine oxidase B inhibitor as the only active ingredient is disclosed for the treatment of Parkinson's disease. The composition is formulated to promote absorption through the buccal, sublingual, pharyngeal and/or esophageal mucous membranes, such that at least 5% of the active ingredient is absorbed in one minute, as determined by a buccal absorption test.
Claims6
A solid dispersible pharmaceutical composition for the treatment of a subject having Parkinson's disease consisting essentially of selegiline or a salt thereof or both selegiline and a salt thereof and one or more matrix forming agents, whereby selegiline is absorbed through the pre-gastric mucosa of the subject when the composition is placed into the oral cavity.
A solid dispersible pharmaceutical composition for the treatment of a subject having Parkinson's disease consisting essentially of selegiline or a salt thereof or both selegiline and a salt thereof and one or more matrix forming agents, which composition disintegrates within 10 seconds of being placed into the oral cavity and whereby selegiline is absorbed through the pre-gastric mucosa of the subject when the composition is placed into the oral cavity.
A solid dispersible pharmaceutical composition for the treatment of a subject having Parkinson's disease comprising as the sole active ingredient selegiline or a salt thereof or both selegiline and a salt thereof and a matrix forming agent, which composition disintegrates within 10 seconds of being placed into the oral cavity and whereby selegiline is absorbed through the pre-gastric mucosa of the subject when the composition is placed into the oral cavity.
Dependencies are inferred from the claim text.