Immunstimulating lipid formulation
AssigneeEurocine AB
InventorUlf Schroder
Life of this patent
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Abstract
A pharmaceutical formulation for parenteral or mucosal administration of antigens and/or vaccines to humans and animals, comprising monglyceride preparations having at least 80% monoglyceride content and where the acyl group contains from 6 to 24 carbon atoms, together with fatty acids where the number of carbon atoms may be varied between 4 and 22.
Claims15
A pharmaceutical formulation for parenteral or mucosal administration of antigens and/or vaccines to an animal, characterized by comprising one or more substances selected from
- a) monoglyceride preparations having at least 80% monoglyceride content and having the general formula
- wherein R1 and R2 is H and R3 is one acyl group containing from 6 to 24 carbon atoms, and where the acyl chains may contain one or more unsaturated bonds
- and
- b) fatty acids of the general formula
- CH3—(CH2)n—COOH
- where “n” may be varied between 4 and 22, and where the acyl chain may contain one or more unsaturated bonds.
A vaccine or antigen formulation, characterized by that 100 g of the final formulation contains:
- from 0.01 to 90 g of the antigen/vaccine component
- from 0.1 to 90 g of the monoglyceride
- from 0.1 to 90 g of the fatty acid
- from 0.01 to 99 g of the water
- from 0.01 to 99 g of PBS/saline
- and optionally one or more adjuvant and/or excipient.
The use of compounds selected from
- a) monoglyceride preparations having at least 80% monoglyceride content and having the general formula
- wherein R1 and R2 is H and R3 is one acyl group containing from 6 to 24 carbon atoms, and where the acyl chains may contain one or more unsaturated bonds
- and
- b) fatty acids of the general formula
- CH3—(CH2)n—COOH
- where “n” may be varied between 4 and 22, and where the acyl chain may contain one or more unsaturated bonds in an amount of 0.01 to 15 g/100 ml of total volume of the formulation as adjuvants/vehicles in pharmaceutical formulations for parenteral or mucosal administration of antigens and/or vaccines to humans or animals, including marine animals.
Dependencies are inferred from the claim text.