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OwnerRobert Graziano, Josephine M. Cardarelli +3inventors
InventorsRobert Graziano, Josephine M. Cardarelli, Thomas D. Kempe, Beth Cutter, Mohan Srinivasan
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The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-5 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-5, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.
An isolated monoclonal antibody, or an antigen-binding portion thereof, wherein the antibody:
An isolated monoclonal antibody, or antigen binding portion thereof, wherein the antibody cross-competes for binding to IRTA-5 with a reference antibody, wherein the reference antibody:
An isolated monoclonal antibody, or an antigen-binding portion thereof, comprising a heavy chain variable region that is the product of a human VH 3-33 gene, a human VH DP44 gene, a human VH 3-23 gene or a human VH 3-7 gene, wherein the antibody specifically binds IRTA-5 amino acid sequence of SEQ ID NO:
An isolated monoclonal antibody, or an antigen-binding portion thereof, comprising a light chain variable region that is the product of a human VK L6 gene, wherein the antibody specifically binds IRTA-5 amino acid sequence of SEQ ID NO:
An isolated monoclonal antibody, or an antigen-binding portion thereof, wherein the antibody:
Dependencies are inferred from the claim text.