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OwnerThomas Boren, Anna Arnqvist +3inventors
InventorsThomas Boren, Anna Arnqvist, Lennart Hammarstrom, Staffan Normark, Dag Ilver
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A novel Helicobacter pylori blood group antigen binding (BAB) adhesin protein was isolated and purified, whereby said protein or fractions thereof bind specifically to fucosylated blood group antigens. The protein sequence of said adhesin is disclosed in this application. Simultaneously the DNA sequences for two genes, babA and babB, producing highly similar proteins, are disclosed. Said adhesin and/or DNA is useful for diagnose and therapy and/or prophylaxis directed against H. pylori induced infections, e.g. gastritis and acid peptic disease, i.e. active vaccination. A new immunoglobulin composition, which exhibits specific activity to a Lewisb antigen binding Helicobacter pylori adhesin, or preferably, monoclonal and/or polyclonal antibodies to said adhesin offer a new and more efficient method of treatment and/or prevention of gastrointestinal diseases, caused by Helicobacter pylori or other Helicobacter species, i.e. passive vaccination.
A vaccine comprising a nucleotide sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:6.
A test kit comprising a monospecific antisera that recognizes a BabA antigen and comprises an immunoglobulin that binds said BabA antigen via a variable region, wherein said Bab A adhesin protein is produced using an isolated and purified bacterial blood group antigen binding protein (BabA) from Helicobacter pylori species, wherein said BabA protein binds specifically to fucosylated Lewisb type I and H-1 blood group antigen-glycoconjugates and,
An isolated monospecific immunoglobulin composition from sera which recognizes a BabA antigen and binds said BabA antigen via a variable region and exhibits specific activity to a BabA adhesion protein from Helicobacter pylori, wherein said adhesin protein binds Lewisb and H-1 blood group antigen-glycoconjugates and is not a HopA, HopB, HopC, HopD or HopE protein.
An isolated monospecific antibody, which recognizes a BabA antigen and binds said BabA antigen via a variable region and exhibits specific activity to a BabA adhesion protein from Helicobacter pylori that binds Lewisb and H-1 blood group antigen-glycoconjugates and is not a HopA, HopB, HipC, HopD or HopE protein.
Dependencies are inferred from the claim text.