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OwnerKyoji Yamaguchi, Hisataka Yasuda +12inventors
InventorsKyoji Yamaguchi, Hisataka Yasuda, Nobuaki Nakagawa, Nobuyuki Shima, Masahiko Kinosaki, Eisuke Tsuda, Masaaki Goto, Kazuki Yano, Akihiro Tomoyasu, Fumie Kobayashi, Naohiro Washida, Ken Takahashi, Tomonori Morinaga, Kanji Higashio
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A novel protein which binds to Osteoclastogenesis Inhibitory Factor (OCIF-binding molecule; OBM), a process for preparing the same, DNA encoding said protein, a protein having an amino acid sequence encoded by this DNA, a method for producing said protein by genetic engineering technique, and a pharmaceutical composition containing said protein. Screening methods for a substance for controlling expression of said protein using said protein and the DNA, a substance which inhibits or modulates the biological activity of said protein, or a receptor which transmits the action of said protein through binding to said protein, the substance obtained by the screening methods, and a pharmaceutical composition which contains this substance. An antibody for said protein, a process for preparing the same, a measuring method of said protein using the antibody, and a medicine comprising this antibody.
1-64. (canceled)
A method of reducing bone resorption in a patient in need thereof, comprising administering to said patient a therapeutic amount of a human monoclonal antibody that binds osteoclastogenesis inhibitory factor-binding molecule (OBM), wherein said therapeutic amount is effective to reduce bone resorption and said OBM consists of the amino acid sequence of SEQ ID NO:11 or SEQ ID NO:17.
A method of inhibiting osteoclast formation in a patient in need thereof, comprising administering to said patient a therapeutic amount of an antibody that binds osteoclastogenesis inhibitory factor-binding molecule (OBM), wherein said therapeutic amount is effective to inhibit osteoclast formation, and wherein said OBM consists of the amino acid sequence of SEQ ID NO:11 or SEQ ID NO:17 and said antibody exhibits a dissociation constant for said OBM between 1×10−11 (M) and 1×10−8 (M).
A method for treating a disease accompanying abnormal bone metabolism comprising administering a therapeutic amount of an antibody that binds osteoclastogenesis inhibitory factor-binding molecule (OBM), wherein said therapeutic amount is effective to reduce bone resorption or inhibit osteoclast formation, and wherein said OBM consists of the amino acid sequence of SEQ ID NO:11 or SEQ ID NO:17 and said antibody does not bind a protein consisting of the amino acid sequence of SEQ ID NO:16.
A method for treating a disease accompanying abnormal bone metabolism comprising administering a therapeutic amount of a human monoclonal antibody that binds osteoclastogenesis inhibitory factor-binding molecule (OBM), wherein said therapeutic amount is effective to reduce bone resorption or inhibit osteoclast formation, and wherein said OBM consists of the amino acid sequence of SEQ ID NO:11 or SEQ ID NO:17.
A human monoclonal antibody which specifically binds to osteoclastogenesis inhibitory factor binding molecule (OBM), wherein said OBM consists of the amino acid sequence of SEQ ID NO:11 or SEQ ID NO:17 and said antibody inhibits bone resorption or inhibits the formation of osteoclasts.
A monoclonal antibody which specifically binds to osteoclastogenesis inhibitory factor binding molecule (OBM), wherein said OBM consists of the amino acid sequence of SEQ ID NO:11 or SEQ ID NO:17 and said antibody inhibits bone resorption or inhibits the formation of osteoclasts and exhibits a dissociation constant for said OBM between an order of 1×10−9 (M) and an order of 1×10−8 (M).
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