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US 2008/0187538 A1Published application
Posh nucleic acids, polypeptides and related methods
AssigneeProteologics, Inc.
InventorsIris Alroy, Tsvika Greener, Shmuel Tuvia, Danny Ben-Avraham
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Abstract
The application discloses novel polypeptides and nucleic acids involved in a variety of biological processes, including viral reproduction. Related methods and compositions are also described.
Claims30
A method of inhibiting viral maturation in a subject in need thereof comprising administering to the subject an agent that inhibits a ubiquitin-related activity of a POSH polypeptide.
A method for identifying an antiviral agent, comprising:
- a) providing a POSH polypeptide and a test agent;
- and
- b) identifying a test agent that interacts with the POSH polypeptide.
A method for testing a ubiquitin-related activity of a POSH (Plenty Of SH3 domains) polypeptide comprising:
- forming a mixture compatible with the ubiquitin-related activity comprising:
- a ubiquitin;
- a ubiquitin-conjugating enzyme (E2);
- and a POSH polypeptide;
- and
- detecting whether said ubiquitin binds to said POSH polypeptide.
3 more elements
Dependencies are inferred from the claim text.