Vaccine
OwnerNormand Blais, Denis Martin +1inventors
InventorsNormand Blais, Denis Martin, Remi M. Palmantier
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Abstract
The present invention relates to fusion proteins comprising an antigen derived from the so-called tumour rejection antigen PRAME (also known as DAGE) linked to an immunological fusion partner which provides T helper epitopes, such as, for example protein D from Haemophilus influenzae B, fusion partner proteins comprising fragments of protein D, methods for preparing the same and for formulating vaccines and use of the same for treating a range of cancers.
Claims58
A fusion protein comprising:
- (a) PRAME or an immunogenic fragment thereof, and
- (b) a heterologous fusion partner protein derived from protein D, wherein the said fusion partner protein does not include the secretion sequence or signal sequence from protein D.
A fusion partner protein derived from protein D, in which the fusion partner protein comprises amino acids Met-Asp-Pro at or within the N-terminus of the fusion protein sequence and in which the fusion partner protein does not include the secretion sequence or signal sequence of protein D.
(canceled)
Dependencies are inferred from the claim text.