Treatment with anti-erbb2 antibodies
AssigneeGenentech, Inc.
InventorSusan D. Hellmann
Life of this patent
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Abstract
The present invention concerns the treatment of disorders characterized by the overexpression of ErbB2. More specifically, the invention concerns the treatment of human patients susceptible to or diagnosed with cancer overexpressing ErbB2 with a combination of an anti-ErbB2 antibody and a chemotherapeutic agent other than an anthracycline, e.g. doxorubicin or epirubicin. The invention further provides a method of treating cancer in a human patient comprising administering effective amounts of an anti-ErbB2 antibody and a cardioprotectant to the patient.
Claims8
A method for the treatment of a human patient with breast cancer that expresses ErbB2 receptor, comprising administering to the patient a combination of an antibody that binds ErbB2 and a hormonal agent that acts to regulate or inhibit hormone action on tumors in an amount effective to extend the time to disease progression in the patient, wherein the antibody binds to epitope 4D5 within the ErbB2 extracellular domain sequence.
A method for the treatment of a human patient with metastatic breast cancer, comprising administering to the patient a combination of an antibody that binds ErbB2 and a hormonal agent that acts to regulate or inhibit hormone action on tumors in an amount effective to extend the time to disease progression in the patient, wherein the antibody binds to epitope 4D5 within the ErbB2 extracellular domain sequence.
Dependencies are inferred from the claim text.