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US 2008/0187530 A1Published application
Novel Agents and Use Thereof
AssigneeLipopeptide AB
InventorsMona Stahle, Johan Heilborn, Margareta Frohm Nilsson, Gunther Weber
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AssigneeLipopeptide AB
InventorsMona Stahle, Johan Heilborn, Margareta Frohm Nilsson, Gunther Weber
Estimating the term…
The present invention provides agents for inhibiting the proliferation of cancer cells, wherein the agent inhibits the biological activity of hCAP18/LL-37. In a preferred embodiment, the agent alters the transcription, translation and/or binding properties of hCAP18/LL-37. Preferably, the agent is selected from the group consisting of short interfering RNA (siRNA) molecules, antisense oligonucleotides and compounds with binding affinity for hCAP18/LL-37. The invention further provides methods for inhibiting the proliferation of cancer cells in a patient, as well as methods and kits for diagnosing cancer.
An agent for inhibiting the proliferation of breast cancer cells, wherein the agent is capable of inhibiting in vivo the biological activity of hCAP18/LL-37.
An agent according to claim wherein the agent inhibits the biological activity of hCAP18/LL-37 by altering the transcription, translation and/or binding properties of hCAP18/LL-37.
A method for detecting breast cancer cells in a patient, the method comprising the following steps:
61-68. (canceled)
Dependencies are inferred from the claim text.