Methods and Compositions for the Repair and/or Regeneration of Damaged Myocardium
AssigneeNew York Medical College
InventorPiero Anversa
Life of this patent
Estimating the term…
Abstract
Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration of stem cells, such as adult stem cells, optionally with cytokines are disclosed and claimed.
Claims29
1-160. (canceled)
A method for restoring functional and structural integrity to damaged myocardium in a patient in need thereof comprising:
- (a) isolating adult hematopoietic stem cells from a bone marrow specimen;
- and
- (b) administering an effective dose of said isolated adult hematopoietic stem cells to the border region of said damaged myocardium in the patient's heart, wherein the functional and structural integrity of the damaged myocardium is restored following stem cell administration.
A method for restoring functional and structural integrity to damaged myocardium in a patient in need thereof comprising:
- (a) isolating adult hematopoietic stem cells from a bone marrow specimen;
- (b) culturing said isolated adult hematopoietic stem cells in vitro, wherein said adult hematopoietic stem cells proliferate and differentiate into myocytes, endothelial cells, and smooth muscle cells, thereby forming cardiac structures;
- and
- (b) implanting said cardiac structures formed in vitro into said damaged myocardium in the patient's heart, wherein the implanted cardiac structures restore functional and structural integrity to the damaged myocardium.
A method for restoring functional and structural integrity to damaged myocardium in a patient in need thereof comprising the administration of an effective dose of one or more cytokines selected from the group consisting of:
- a. a stem cell factor;
- b. a granulocyte-colony stimulating factor;
- c. a stromal cell-derived factor-1;
- d. an interleukin-3;
- e. a granulocyte-macrophage colony stimulating factor;
- f. a macrophage colony stimulating factor;
- g. a vascular endothelial cell growth factor;
- and combinations thereof, wherein the functional and structural integrity of the damaged myocardium is restored following cytokine administration.
Dependencies are inferred from the claim text.