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US 2008/0187513 A1Published application
Treatment of Solid Cancers
AssigneePeplin Research Pty. Ltd.
InventorsSteven Martin Ogbourne, Andreas Suhrbier
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AssigneePeplin Research Pty. Ltd.
InventorsSteven Martin Ogbourne, Andreas Suhrbier
Estimating the term…
The present invention relates generally to the field of cancer including tumor therapy. More particularly, the present invention relates to the treatment of solid cancers, including solid tumors, and the prevention or reduction of cancer metastasis, by chemoablation of cancer cells by an agent which also stimulates the generation of cancer-specific T-cells, a process referred to herein as immunostimulatory chemoablation. The present invention further contemplates combination therapy comprising immunostimulatory chemoablation and one or more other therapeutic regimens, which enhance, co-operate and/or synergize with the cancer-specific T-cells induced by the chemoablation. The present invention also relates to pharmaceutical compositions for use in treating cancers.
A method for treating or preventing cancer growth and/or metastasis in a subject, said method comprising administering directly or proximally to said cancer, one or more angeloyl substituted ingenanes in an amount effective to induce necrosis in at least the cancer cells and to stimulate the generation of cancer-specific T-cells.
A method for treating a secondary cancer in a subject, said method comprising administering an angeloyl substituted ingenane or a derivative thereof directly to proximal to a primary cancer in an amount effective to induce primary necrosis in at least the cancer cells and to stimulate the generation of anti-cancer-specific T-cells.
A pharmaceutical composition comprising an angeloyl substituted ingenane and at least one agent capable of enhancing, co-operating or synergizing with cancer-specific T-cells said composition further comprising pharmaceutically acceptable carrier, diluent or excipient.
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Dependencies are inferred from the claim text.