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AssigneesUniversity of Pittsburgh - Of the Commonwealth, System of Higher Education
InventorsMichael R. Shurin, Valerian E. Kagan, Galina V. Shurin, Yulia Tyurina
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The invention provides an oil-based pharmaceutical composition comprising as an active ingredient phostphatidylserine or a derivative thereof and a pharmaceutically acceptable oil-based carrier, which is formulated for topical or intratumoral administration. Preferably, the composition is an ointment or a cream. The composition can contain additional active agents as well, such as aminophospholipid translocase inhibitors, transnitrosylating agents, chemokines, cytokines, Toll-like receptor ligands, imidazoquinolines, dendritic cell differentiation factors, or combinations thereof. In another aspect, the invention provides a method of treating cancer within a patient in need of treatment by administering the inventive composition to the patient.
A pharmaceutical composition comprising as an active ingredient phosphatidylserine (PS) or a derivative thereof and a pharmaceutically acceptable oil-based carrier, wherein the composition is formulated for topical administration.
A method of treating a neoplastic disorder in a human patient comprising topically applying to the human patient a pharmaceutical composition in an amount and at a location sufficient to treat the neoplastic disorder within the human patient, the composition comprising as an active ingredient phosphatidylserine (PS) or a derivative thereof and a pharmaceutically acceptable oil-based carrier and wherein the neoplastic disorder is oral cancer, rectal cancer, head and neck cancer, epithelial cancer, melanoma, basal cell carcinoma, squamous cell carcinoma, or lymphoma.
Dependencies are inferred from the claim text.