Phage antibodies to radiation-inducible neoantigens
AssigneeVanderbilt University
InventorsDennis E. Hallahan, Raymond Mernaugh
Life of this patent
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Abstract
A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor.
Claims21
1-22. (canceled)
An immunoconjugate composition comprising a single chain fragment variable (scFv) antibody or an Fab antibody that binds to a radiation-inducible neoantigen.
A polyvalent immunoconjugate composition, the polyvalent immunoconjugate composition comprising a plurality of antibodies or antibody fragments selected from the group consisting of single chain fragment variable (scFv) antibodies, Fab antibodies, and combinations thereof, wherein the plurality of antibodies or antibody fragments bind to a plurality of different epitopes, and wherein at least one of the epitopes is present on a radiation-inducible neoantigen.
38-53. (canceled)
Dependencies are inferred from the claim text.