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US 2008/0187487 A1Published application
Methods for producing multilayered particles, fibers and sprays and methods for administering the same
OwnerGustavo LARSEN, Ruben SPRETZ +3inventors
InventorsGustavo LARSEN, Ruben SPRETZ, Raffet VELARDE-ORTIZ, David VU, Luis NUNEZ
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Abstract
Capsules and particles with at least one encapsulated and/or entrapped agent, such as therapeutic agent, imaging agents, and other constituents may be produced by electrohydrodynamic processes. More particularly, the agent encapsulated in a vehicle, capsule, particle, vector, or carrier may maximize treatment and/or imaging of malignant cancers while minimizing the adverse effects of treatment and/or imaging.
Claims60
A method of producing a capsule having at least one encapsulated agent, said method comprising:
- supplying a core fluid to an interior of a hollow tube;
- supplying a shell fluid flow;
- generating a shell fluid flow to an external wall of the hollow tube;
- subjecting the core fluid and the shell fluid to an electric potential so as to form a two-fluid electrified jet at an apex of the hollow tube;
- forming a capsule having a core region and a shell region at the apex of the hollow tube.
2 more elements
A capsule, comprising:
- a core region;
- a shell region such that the shell region includes pores having a size in the range of about 0.5 nm to about 2.0 nm;
- at least one entrapped an/or encapsulated agent;
- and
- a functional group dispersed on a surface of the shell region.
2 more elements
Dependencies are inferred from the claim text.