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US 2008/0185327 A1Published application
Disposable monolithic column
AssigneeDionex Corporation
InventorShaofeng Xie
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AssigneeDionex Corporation
InventorShaofeng Xie
Estimating the term…
Permeable polymeric monolithic materials are prepared in a plastic column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized by the application of heat from an external source starting at a low temperature such as 40 degrees centigrade, depending on the mixture and size of the column, and continuing at a higher temperature, such as 60 degrees centigrade. The temperature at the start of the polymerization is low enough so as not to cause exothermal run-away conditions and to avoid high heat of reaction that would prevent a substantially constant temperature across the cross-section of the column. The higher temperature is used after sufficient monomer depletion has occurred and steric interference has increased so the polymerization reaction is sufficiently slow to avoid heat of reaction generation high enough to cause significant reduction in the homogeneousness of the pore sizes.
1-55. (canceled)
A chromatographic system comprising:
A separating system comprising:
A method of controlling polymerization of a monolithic polymer plug suitable for use in a separating device comprising the steps of:
A method of polymerizing a mixture to form a solid support suitable for use in a separating device containing at least one monomer and a porogen comprising the step of irradiating the mixture with x-rays during polymerization to form a monolithic polymer plug.
Dependencies are inferred from the claim text.