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US 2008/0176216 A1Published application
Multifunctional Encoded Particles for High-Throughput Analysis
AssigneeMassachusetts Institute of Technology
InventorsPatrick S. Doyle, Daniel C. Pregnibon
Life of this patent
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Abstract
Method for making multifunctional particles. The method includes flowing a first monomer stream loaded with a fluorescent entity along a microfluidic channel and flowing a second monomer stream loaded with a probe adjacent to the first monomer stream along the microfluidic channel. The monomer streams are polymerized to synthesize particles having a fluorescent, graphically encoded region and a probe-loaded region.
Claims25
Method for making multifunctional particles comprising:
- flowing a first monomer stream loaded with a fluorescent entity along a microfluidic channel;
- flowing a second monomer stream loaded with a probe adjacent to the first monomer stream along the microfluidic channel;
- and
- polymerizing the monomer streams to synthesize particles having a fluorescent, graphically encoded region and a probe-loaded region.
1 more element
Multifunctional particle comprising:
- at least one graphically encoded region that is covalently linked to at least one region loaded with a probe.
High-throughput screening system comprising:
- multifunctional particles having a graphically encoded region and a probe-loaded region;
- and
- a flow-focusing microfluidic device adapted to align and read the particles.
Dependencies are inferred from the claim text.