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OwnerNiels Brunner, John Romer +6inventors
InventorsNiels Brunner, John Romer, Vincent Ellis, Charles Pyke, Jan Grondahl-Hansen, Helle Pedersen Pappot, Heine Hoi Hansen, Keld Dano
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The present invention relates to methods for inhibiting malignant tumour growth, invasion and/or metastasis in a patient, the method comprising suppressing the inhibitory activity of an inhibitor of a protease or of a non-proteolytic matrix-degrading enzyme (IPNME) in malignant tumour tissue or potential malignant tumour tissue. The suppression may be brought about by administering compounds interacting with the IPNME, but also administration of compounds interacting with transcription of genes encoding the IPNME is a possibility. The invention also relates to methods of selecting and identifying compounds in the therapeutical methods, as well of the use of such compounds in the treatment of malignancies.
A method of inhibiting malignant tumor growth, invasion and/or metastasis in a subject, said malignant tumor growth, invasion and/or metastasis being associated with activity in malignant tumor tissue of an inhibitor of a metalloprotease, which comprises administering to the subject a suppressive amount of a suppressor of said metalloprotease inhibitor, whereby malignant tumor growth, invasion and/or metastasis is inhibited.
A method of suppressing the inhibitory activity of a metalloprotease inhibitor in malignant tumor tissue of a subject, which comprises contacting said tissue with a suppressive amount of a suppressor of said metalloprotease inhibitor, wherein
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