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US 2008/0090750 A1Published application
Novel Antiangiogenic Peptide Agents and Their Therapeutic and Diagnostic Use
AssigneeThe Regents of the University of California
InventorsRichard Weiner, Joseph Martial, Ingrid Struman, Robert Taylor, Frauke Bentzien
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Abstract
The current invention concerns novel antiangiogenic peptides which correspond to about 10 to about 150 consecutive amino acids of N-terminal sequences of human growth hormone, human placental lactogen, human growth hormone variant hGH-V, and prolactin, and their use in inhibiting angiogenesis and in the diagnosis of diseases of human pregnancy involving abnormalities of placental vascularization.
Claims15
1-26. (canceled)
An isolated peptide having the amino acid sequence of SEQ ID NO:
- 18 or having an amino acid sequence that has 90% sequence identity with the amino acid sequence of SEQ ID NO:18.
A pharmaceutical formulation, comprising:
- a therapeutically effective amount of an isolated peptide that has the amino acid sequence of SEQ ID NO:18 or that has 90% sequence identity with the amino acid sequence of SEQ ID NO:18;
- and
- a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.