Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is associated
AssigneeUniversity of Washington
InventorsMartin Cheever, Mary Disis
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AssigneeUniversity of Washington
InventorsMartin Cheever, Mary Disis
Estimating the term…
Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immunocomplexes formed between the HER-2/neu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2/neu oncogene is associated. The present invention also discloses methods and compositions, including peptides, for treating such malignancies.
1-14. (canceled)
An isolated peptide consisting of one of the amino acid sequences:
Dependencies are inferred from the claim text.