Formulations of sitaxsentan sodium
OwnerJinling Chen, Sandy Koppenol +4inventors
InventorsJinling Chen, Sandy Koppenol, Lian Rajewski, Andrew Trammel, Kent Amsberry, Aaron Schoeneman
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Abstract
Provided herein are stable lyophilized and oral formulations of sitaxsentan sodium. In certain embodiments the lyophilized formulations provided herein have improved stability upon reconstitution. Also provided are methods of making and using the formulations.
Claims75
A lyophilized powder comprising sitaxsentan sodium, an antioxidant, a buffer and a bulking agent.
An oral tablet comprising sitaxsentan sodium, an antioxidant, a binding agent, a diluent, a buffer and a moisture resistant coating.
A process for preparing a lyophilized powder, comprising:
- mixing sitaxsentan sodium with a solution comprising an antioxidant, a buffer and a sugar to produce a solution thereof;
- and
- lyophilizing the solution to produce a powder.
An oral tablet comprising sitaxsentan sodium and a buffer.
An oral tablet comprising sitaxsentan sodium and a moisture barrier coating.
An oral tablet comprising sitaxsentan sodium and an antioxidant.
Dependencies are inferred from the claim text.