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AssigneesDr.Reddy's Laboratories Ltd., Dr.Reddy's Labratories, Inc.
InventorsVenkateswarlu Akella, Shanavas Alikunju, Ajaya Reka, Ramesh Mullangi, Raju Sirisilla, Subrahmanyam Duvvuri, Sriram Rajagopal
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A 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2′-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2′-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutical compositions of the 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diastereoisomer are also described as are methods of using the compound for the inhibition of topoisomerase I and for the treatment of cancer.
5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin which is substantially free of 5(R)-(2′-hydroxyethoxy)-20(S)-camptothecin.
A method of inhibiting the activity of topoisomerase I in a cell, the method comprising administering to the cell a topoisomerase I inhibiting effective amount of 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin which is substantially free of 5(R)-(2′-hydroxyethoxy)-20(S)-camptothecin.
Dependencies are inferred from the claim text.