Anti-Inflammatory Agents

A pharmaceutical composition comprising, as active ingredient, a compound of formula (I):

• wherein
• y is any integer from 1 to 8;
• z is any integer from 1 to 8, with the proviso that y and z cannot both equal 1;
• X is —CO—(Y)k—(R1)n or SO2—(Y)k—(R1)n;
• k is 0 or 1;
• Y is a cycloalkyl, polycyloalkyl, cycloalkenyl or polycycloalkenyl group;
• each R1 is independently selected from hydrogen or an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms;
• or each R1 is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical;
• and
• n is any integer from 1 to m, where m is the maximum number of substitutions permissible on the cyclo-group Y;
• or
• alternatively R1 is selected from a peptido radical having from 1 to 4 peptidic moieties linked together by peptide bonds;
• or
• a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient and/or carrier.

A compound of general formula (I):

• wherein
• y is any integer from 1 to 8;
• z is any integer from 1 to 8, with the proviso that y and z cannot both equal 1;
• X is CO—(Y)k—(R1)n or SO2—(Y)k—(R1)n;
• k is 0 or 1;
• Y is a cycloalkyl, polycyloalkyl, cycloalkenyl or polycycloalkenyl group;
• each R1 is independently selected from hydrogen or an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms;
• or
• each R1 is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical;
• and
• n is any integer from 1 to m, where m is the maximum number of substitutions permissible on the cyclo-group Y;
• or
• R1 is selected from a peptido radical having from 1 to 4 peptidic moieties linked together by peptide bonds.

A method to prevent, inhibit or treat an inflammatory disorder, comprising administering to a patient an effective amount of a compound of formula (I):

• wherein
• y is any integer from 1 to 8;
• z is any integer from 1 to 8;
• with the proviso that y and z cannot both equal 1;
• X is —CO—(Y)k—(R1)n or SO2—(Y)k—(R1)n;
• k is 0 or 1;
• Y is a cycloalkyl, polycyloalkyl, cycloalkenyl or polycycloalkenyl group;
• each R1 is independently selected from hydrogen or an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms;
• or each R1 is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical;
• and
• n is any integer from 1 to m, where m is the maximum number of substitutions permissible on the cyclo-group Y;
• or
• R1 is selected from a peptido radical having from 1 to 4 peptidic moieties linked together by peptide bonds;
• or a pharmaceutically acceptable salt thereof.