Adenovirus vectors containing cell status-specific response elements and methods of use thereof
AssigneeCell Genesys, Inc.
InventorsDe Yu, Daniel Henderson
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Abstract
The present invention provides adenoviral vectors comprising cell status-specific transcriptional regulatory elements which confer cell status-specific transcriptional regulation on an adenoviral gene. A “cell status” is generally a reversible physiological and/or environmental state. The invention further provides compositions and host cells comprising the vectors, as well as methods of using the vectors.
Claims28
An adenovirus vector comprising an adenovirus gene under transcriptional control of a transcriptional regulatory element (TRE) comprising a cell status-specific Tre.
An adenovirus vector comprising an adenovirus gene under transcriptional control of a TRE comprising a cell status-specific TRE and a cell-type specific TRE.
Dependencies are inferred from the claim text.