Gliclazide nanosphere and manufacturing method therefor and application thereof
AssigneeKaohsiung Medical University
InventorsYung-Kuang Lo, Thau-Ming Cham
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Abstract
An novel gliclazide nanosphere, the manufacturing method therefor and the application thereof are provided in the present application is provided. The gliclazide nanosphere is prepared by reacting the solid gliclazide with a polymeric matrix for improving the dissolution property and safety of gliclazide, and is benefit for immediately releasing dosage application in clinical therapy.
Claims14
A manufacturing method for a gliclazide nanosphere, comprising steps of:
- providing a first solution comprising:
- a solute having a gliclazide and an acrylic resin;
- and
- a solvent having an acetone and a methanol;
- providing a second solution having a polyvinyl alcohol and a water;
- pouring the first solution into the second solution to be stirred at 400-600 rpm for 5-10 min to obtain the gliclazide nanosphere.
A gliclazide nanosphere prepared by a manufacturing method, wherein the manufacturing method comprising steps of:
- providing a first solution comprising:
- a solute having a gliclazide and an acrylic resin;
- and
- a solvent having an acetone and a methanol;
- providing a second solution having a polyvinyl alcohol and a water;
- pouring the first solution into the second solution to be stirred at 400-600 rpm for 5-10 min to obtain the gliclazide nanosphere.
A high gliclazide concentration solution, comprising a gliclazide nanosphere prepared by a manufacturing method, wherein the manufacturing method comprising steps of
- providing a first solution comprising:
- a solute having a gliclazide and an acrylic resin;
- and
- a solvent having an acetone and a methanol;
- providing a second solution having a polyvinyl alcohol and a water;
- pouring the first solution into the second solution to be stirred at 400-600 rpm for 5-10 min to obtain the gliclazide nanosphere.
A pharmaceutical composition, comprising a pharmaceutically acceptable carrier and a pharmaceutically effective gliclazide nanosphere prepared by a manufacturing method, wherein the manufacturing method comprising steps of
- providing a first solution comprising:
- a solute having a gliclazide and an acrylic resin;
- and
- a solvent having an acetone and a methanol;
- providing a second solution having a polyvinyl alcohol and a water;
- pouring the first solution into the second solution to be stirred at 400-600 rpm for 5-10 min to obtain the gliclazide nanosphere.
Dependencies are inferred from the claim text.