Tamsulosin controlled-release tablet

An osmotic pump device for administration of the active ingredient tamsulosin or a pharmaceutically acceptable salt thereof at a controlled rate into the gastrointestinal tract comprising:

• a) a core comprising a first layer containing a pharmaceutically effective amount of tamsulosin or a pharmaceutically acceptable salt thereof and about 10 to 99 percent by weight of said first layer of polyvinylpyrrolidone polymers and/or copolymers, and a second layer comprising about 10 to 80 percent by weight of said second layer of water-insoluble volume-swellable polymers, about 80 to 10 percent by weight of said second layer of water-soluble osmopolymers, and about 5 to 50 percent by weight of said second layer of osmagents;
• b) a wall surrounding said core comprising a semi-permeable material permeable to the passage of an exterior fluid present in said gastrointestinal tract and substantially impermeable to the passing of said tamsulosin or pharmaceutically acceptable salt thereof;
• and
• c) a passageway in said wall communicating with said first layer and the exterior of said device for delivery of said tamsulosin or pharmaceutically acceptable salt thereof from said device.