Hydrophobic opioid abuse deterrent delivery system using opioid antagonists

(canceled)

(canceled)

(canceled)

(canceled)

(canceled)

(canceled)

(canceled)

(canceled)

(canceled)

A method of providing an opioid therapeutic agent to a patient comprising providing the patient with a monolithic solidified oral dosage form prepared by a thermal process, the oral dosage form comprising the opioid therapeutic agent, an opioid antagonist, and a hydrophobic matrix material wherein the oral dosage form releases at least 80% of the opioid therapeutic agent after 2 hours of stirring in a 0.1 N HCl solution and 16 hours stirring in a pH 6.8 phosphate buffer solution using a USP Type II paddle apparatus at 75 rpm and 37° C., and wherein the oral dosage form releases less than 40% of the hydromorphone and/or pharmaceutically acceptable salts of hydromorphone after 5 minutes of shaking at 240 cycles/min in a 0.1 N HCl solution and 3 hours of shaking on an orbital shaker at 240 cycles/min in an aqueous solution of 40% ethanol at 25° C.;

• and
• wherein the opioid antagonist is sequestered from the opioid therapeutic agent such that the opioid antagonist has no substantial effect on the activity of the opioid therapeutic agent when the dosage form is taken orally as prescribed, but the opioid antagonist is released in an amount that reduces the effectiveness of the opioid therapeutic agent contained in the dosage form when the dosage form is crushed.

33-63. (canceled)

65-98. (canceled)