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US 2008/0075767 A1Published application
Ibuprofen-containing liquid filled hard capsules
OwnerXiao Jin, Chandir Ramani +5inventors
InventorsXiao Jin, Chandir Ramani, Lester Fulper, Tak Law, Dawn Downey, Anil Kane, David Wynn
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Abstract
The present invention relates to ibuprofen-containing pharmaceutically acceptable solutions for filling hard capsules.
Claims4
A pharmaceutically acceptable solution for filling a hard capsule comprising, based upon the total weight of the solution:
- (a) from about 45 to about 75% by weight ibuprofen,
- (b) from about 3 to about 5% by weight of an alkylizing agent, and
- (c) from about 30 to about 46% by weight of a solvent selected from the group consisting of a vegetable oil, a polyglycolized glyceride, a combination of polyethylene glycol and a polyoxyethylene stearate, and combinations thereof,
- wherein the molar ratio between the alkylizing agent and ibuprofen is about 1:about 1.
1 more element
A pharmaceutically acceptable solution for filling a hard capsule comprising, based upon the total weight of the solution:
- (a) from about 60% by weight ibuprofen,
- (b) from about 3% by weight of potassium hydroxide and
- (c) from about 37% by weight of a combination of polyethylene glycol and a polyoxyethylene stearate,
- wherein the molar ratio between the potassium hydroxide and ibuprofen is about 1:about 1.
1 more element
Dependencies are inferred from the claim text.