Dispersions of microemulsions in hydrogels for drug delivery
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsAnuj Chauhan, Derya Gulsen
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Abstract
An ophthalmically bioactive agent delivery system comprising a contact lens having dispersed therein as an oil-in-water microemulsion, an ophthalmically bioactive agent encapsulated in the oil phase, the oil phase comprising a material from which the agent VAN diffuse into and migrate through the contact lens into the post-lens tear film when the contact lens is placed on the eye and wherein the microemulsion is stabilized by the presence of a surfactant with sufficient packing at the oil-water interface to attenuate the rate of diffusion into and migration of agent through the contact lens.
Claims10
An ophthalmically bioactive agent delivery system comprising a contact lens having dispersed therein as an oil-in-water microemulsion, an ophthalmically bioactive agent encapsulated in the oil phase of the microemulsion, the oil phase comprising an ophthalmically acceptable material from which the agent is capable of diffusion into and migration through the contact lens and into the post-lens tear film when the contact lens is placed on the eye and wherein the microemulsion is stabilized by the presence of an ophthalmically acceptable surfactant with sufficient packing at the oil-water interface to attenuate the rate of diffusion into and migration of agent through the contact lens.
A bioactive agent delivery system of claim 4 wherein said hydrophilic monomer is an unsaturated carboxylic acid;
- acrylic substituted alcohol;
- vinyl lactam or acrylamide.
A bioactive agent delivery system of claim 5 wherein said hydrophilic monomer is a methacrylic or acrylic acid, 2-hydroxyethylmethacrylate, 2-hydroxyethylacrylate, N-vinyl pyrrolidone, methacrylamide or N,N-dimethylacrylamide.
A kit and its use for the storage and delivery of ophthalmic drugs to the eye, the kit comprising:
- c) a first component containing at least one of the above described drug delivery systems, and
- d) a second component containing at least one storage container for the first component, the storage container additionally containing a material that substantially prevents the diffusion and migration of the ophthalmic drug during storage.
An article of manufacture comprising packaging material and the above described drug delivery system or the above-described kit contained within the packaging material, wherein the packaging material comprises a label which indicates that the drug delivery system and kit can be used for ameliorating symptoms associated with pathologic conditions of the eye.
Dependencies are inferred from the claim text.