Back to results
US 2008/0075728 A1Published application
Combination Therapies Of Hmgb And Complement Inhibitors Against Inflammation
OwnerWalter Newmaninventor
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
OwnerWalter Newmaninventor
Estimating the term…
Compositions and methods are disclosed for treating a condition characterized by activation of an inflammatory cytokine cascade in a patient. The compositions comprise an HMGB A box and an inhibitor of complement biological activity, and/or an antibody that binds an HMGB polypeptide or biologically active fragment thereof and an inhibitor of complement biological activity, and/or an inhibitor of HMGB receptor binding and an inhibitor of complement biological activity. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of proinflammatory cytokine(s) and/or inhibit the inflammatory cytokine cascade.
A pharmaceutical composition comprising a polypeptide and an agent that inhibits complement biological activity, wherein said polypeptide comprises a high mobility group box (HMGB) A box or a biologically active fragment thereof.
A pharmaceutical composition comprising an antibody or antigen-binding fragment thereof that binds an HMGB polypeptide or a fragment thereof and an agent that inhibits complement biological activity.
A pharmaceutical composition comprising an inhibitor of HMGB receptor binding and/or HMGB signaling and an agent that inhibits complement biological activity.
A method of treating an inflammatory condition in a patient comprising administering to said patient a composition comprising a polypeptide and an agent that inhibits complement biological activity, wherein said polypeptide comprises a high mobility group box (HMGB) A box or a biologically active fragment thereof.
A method of treating an inflammatory condition in a patient comprising administering to said patient a composition comprising an antibody or an antigen-binding fragment thereof and an agent that inhibits complement biological activity, wherein said antibody or antigen-binding fragment thereof binds an HMGB polypeptide or a fragment thereof.
A method of treating an inflammatory condition in a patient comprising administering to said patient a composition comprising an inhibitor of HMGB receptor binding and/or HMGB signaling and an agent that inhibits complement biological activity.
A pharmaceutical composition comprising an agent that inhibits HMGB biological activity and an agent that inhibits complement biological activity.
A method of treating an inflammatory condition in a patient comprising administering to said patient a composition comprising an agent that inhibits HMGB biological activity and an agent that inhibits complement biological activity.
Dependencies are inferred from the claim text.