Back to results
US 2008/0075658 A1Published application
Method of Radiolabeling Formulations for Gamma Scintigraphy Assessment
OwnerMatthew Burke, Jeffrey Statoninventors
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
OwnerMatthew Burke, Jeffrey Statoninventors
Estimating the term…
The present invention is directed to a novel method for producing a radiolabeled product for use in gamma scintigraphy, preferably for use with gastric retentive formulations. One aspect of the invention is the process which comprises adsorbing a suitable radionuclide onto a substrate, such as activated charcoal, and blending this nuclide/substrate product with an insoluble polymer; forming a melt blend of the polymer mix, cooling the melt blend to form a solid, and then breaking the solid into smaller particles. Suitably, the temperature of the melt blend is high enough to melt the polymer but not enough to degrade the polymeric material.
A process for producing a radiolabeled product, which comprises
The process according to claim 3 wherein the water/acid mixture uses hydrochloric acid, phosphoric acid or acetic acid.
A process for producing a radiolabeled product which comprises
A method of producing a radiolabeled gastroretentive formulation (GRF) for use in a human in need thereof, which comprises incorporating into a gastroretentive formulation a radionuclide incorporated into an electrospun fiber, a melt extruded fiber, a melt extruded granule, or an electrosprayed bead.
A pharmaceutical composition comprising an effective amount of a radionuclide and activated charcoal.
A pharmaceutical composition comprising an effective amount of a radionuclide, activated charcoal, and an insoluble polymer.
Dependencies are inferred from the claim text.