Sterilized minocycline and rifampin-containing medical device
AssigneeMedtronic, Inc.
InventorsDianne Judd, Jennifer Raeder-Devens, William Ferris
Life of this patent
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Abstract
A sterilized medical device comprising minocycline and rifampin is described. The device is setrerilized by e-beam raditation such that degradation of minocycline and rifampin is minimized. Methods for sterilizing minocycline and rifampin-containing devices by e-beam radiation and methods of manufacturing devices, which methods include e-beam sterilization, are also described.
Claims21
A method for sterilizing a rifampin and minocycline-containing medical device, comprising:
- sterilizing the device with e-beam radiation,
- wherein (i) the amount of minocycline recoverable from the device after sterilization is 90% or more of the amount of minocycline recoverable from the device prior to sterilization, and (ii) the amount of rifampin recoverable from the device after sterilization is 90% or more of the amount of rifampin recoverable from the device prior to sterilization.
A method for manufacturing a medical device, comprising:
- incorporating rifampin and minocycline in, on or about at least a portion of the medical device;
- and
- sterilizing the at least a portion of the medical device with e-beam radiation,
- wherein (i) the amount of minocycline recoverable from the device after sterilization is 90% or more of the amount of minocycline recoverable from the device prior to sterilization, and (ii) the amount of rifampin recoverable from the device after sterilization is 90% or more of the amount of rifampin recoverable from the device prior to sterilization.
A medical device sterilized by e-beam radiation, the device comprising a polymeric material incorporating minocycline and rifampin,
- wherein (i) the amount of minocycline recoverable from the device after sterilization is 90% or more of the amount of minocycline recoverable from the device prior to sterilization, and (ii) the amount of rifampin recoverable from the device after sterilization is 90% or more of the amount of rifampin recoverable from the device prior to sterilization
A sterilized medical device comprising a polymeric material incorporating minocycline and rifampin, the device made by a process comprising:
- incorporating rifampin and minocycline in, on or about at least a portion of the medical device;
- and
- sterilizing the at least a portion of the medical device with e-beam radiation,
- wherein (i) the amount of minocycline recoverable from the device after sterilization is 90% or more of the amount of minocycline recoverable from the device prior to sterilization, and (ii) the amount of rifampin recoverable from the device after sterilization is 90% or more of the amount of rifampin recoverable from the device prior to sterilization
Dependencies are inferred from the claim text.