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US 2008/0074644 A1Published application
Sample imaging and classification
AssigneeCambridge Research & Instrumentation, Inc.
InventorsRichard Levenson, Clifford Hoyt
Life of this patent
Estimating the term…
Abstract
Disclosed herein are methods and apparatus for obtaining at least one absorption image and at least one birefringence image of a stained sample.
Claims25
A method, comprising:
- obtaining at least one absorption image and at least one birefringence image of a stained sample.
An apparatus, comprising:
- a microscope imaging system configured to obtain at least one absorption image and at least one birefringence image of a stained sample;
- and
- an electronic processor coupled to the microscope imaging system and configured to receive information about one or more stains in the stained sample, to combine information from the at least one absorption image and the at least one birefringence image, and to identify structural entities in the sample based on at least a portion of the combined information derived from the at least one birefringence image.
A method, comprising:
- identifying collagen in a stained tissue sample, wherein the identifying comprises obtaining at least one absorption image of the sample by measuring light absorption by one or more stains in the sample that are not specific for collagen, obtaining at least one birefringence image of the sample, combining information derived from the at least one absorption image and the at least one birefringence image, and identifying collagen based on a portion of the combined information derived from the at least one birefringence image.
Dependencies are inferred from the claim text.