Biaryl Derivatives

A compound represented by the formula (I):

• wherein X1 is N or CR2, X2 is N or CR4,
• R1, R2, R3 and R4 are each independently hydrogen, halogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted acyl, carboxy, or optionally substituted lower alkoxycarbonyl, provided that all of R1 to R4 are not simultaneously hydrogen,
• wherein R5 and R6 are each independently hydrogen, halogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted amino, or cyano, and when a broken line is a single bond, then R5 may be oxo,
• Y is:
• wherein RA, RB and RE are each independently hydrogen or lower alkyl
• RC and RD are each independently hydrogen, optionally substituted lower alkyl and RC and RD may be taken together to form a carbocycle containing an adjacent carbon atom,
• RF is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted amino, optionally substituted amidino, cyano, optionally substituted aryl, or optionally substituted heterocycle,
• RG is optionally substituted lower alkyl, optionally substituted aryl, or optionally substituted heterocycle,
• RH and RJ are each independently hydrogen, optionally substituted lower alkyl, carboxy, or optionally substituted lower alkoxycarbonyl,
• p is 1 or 2,
• ring A is:
• wherein X3 is O, S or NR13,
• X4 is CR7 or N, X5 is CR8 or N, X6 is CR9 or N, X7 is CR10 or N, provided that at least one of X4 to X7 is N, and at least one of X4 to X7 is other than N, R7 to R12 are each independently hydrogen, halogen, hydroxy, lower alkyl, lower alkenyl, lower alkoxy, carboxy, lower alkoxycarbonyl, acyl, acyloxy, lower alkylsulfonyloxy or arylsulfonyloxy,
• R13 and R14 are each independently hydrogen, lower alkyl, lower alkoxycarbonyl or aryl(lower)alkyl,
• W is hydrogen, optionally substituted lower alkyl, NR15R16, OR17, SR18, COR19 or CONR20R21, when ring A is (A1), and R5 is lower alkyl, then W is NR15R16, SR18, COR19 or CONR20R21,
• R15 and R16 are each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted cycloalkyl, optionally substituted carbamoyl, optionally substituted lower alkylsulfonyl, optionally substituted arylsulfonyl, optionally substituted aryl, or optionally substituted heterocycle,
• R17, R18, R19, R20 and R21 are each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted cycloalkyl, optionally substituted aryl, or optionally substituted heterocycle,
• or a pharmaceutically acceptable salt, or a solvate thereof.