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US 2007/0066575 A1Published application
Methods and compositions for mitigating pain
AssigneeQueen's University at Kingston
InventorsGregory Thatcher, Brian Bennett, James Reynolds, Khem Jhamandas
Life of this patent
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Abstract
Methods and therapeutic compounds for treating pain, mitigating inflammation, effecting analgesia and/or effecting sedation in a subject are described. A subject is administered an effective amount of a therapeutic compound which is a nitrate ester. Novel pharmaceutical compositions are also described.
Claims1
A method for treating pain in a subject in need thereof, comprising administering to the subject an effective amount of a therapeutic compound, wherein said therapeutic compound is of the formula (Ia):
- F2 is a nitrate group or an organic radical which may be joined in a cyclic ring system with
- G2, and which may contain inorganic counterions;
- E is a methylene group;
- G1 is a methylene group or does not exist;
- F1 is H;
- and
- G2 is joined with F2 to form a cyclic system or is RN-ZN;
- wherein RN is an organic radical possessing a heteroaryl group containing a P or S atom, where said P or S is positioned β, γ, or δ to a nitrate group;
- and ZN is WNnwn-XNnn-YNoo;
- wherein
- mm, nn, oo are 0 or 1 and WN, XN, YN are NH, NRNN, CO, O, or CH2;
- wherein
- RNN is a C1-C12 alkyl group.
10 more elements
Dependencies are inferred from the claim text.