Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
AssigneeAventis Pasteur Limited
InventorsLynn Doucette-Stamm, David Bush, Qiandong Zeng, Timothy Opperman, Chad Houseweart
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Abstract
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
Claims9
An isolated nucleic acid encoding a S. pneumoniae polypeptide comprising SEQ ID NO:
- 5200.
An isolated nucleic acid sequence comprising SEQ ID NO:
- 2539.
An isolated nucleic acid sequence selected from the group consisting of:
- a) SEQ ID NO:
- 2539,
- b) a nucleic acid sequence having at least about 90% identity to SEQ ID NO:
- 2539,
- c) a complement of SEQ ID NO:
- 2539,
- d) a complement of a nucleic acid sequence having at least about 90% identity to SEQ ID NO:
- 2539, and
- e) an RNA of a), b), c) or d), wherein U is substituted for T.
An isolated nucleic acid comprising a nucleotide sequence that hybridizes under high stringency conditions to at least one member selected from the group consisting of:
- a) SEQ ID NO:
- 2539,
- b) a complement of SEQ ID NO:
- 2539,
- c) an RNA of a) or b), wherein U is substituted for T.
An isolated nucleic acid comprising at least about 40 consecutive nucleotides that hybridizes under high stringency conditions to SEQ ID NO:
- 2539.
Dependencies are inferred from the claim text.